SIRT1 Polyclonal Antibody — image 1 of 2

Product details

SIRT1 Polyclonal Antibody

Catalog number E-AB-70071-01

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Price for E-AB-70071-01

Size / count 60 µL

Specifications

Catalog number: E-AB-70071-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: SIRT1, also named as SIR2L1, contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection, including: activation of endothelial nitric oxide synthase, insulin receptor signalling, and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO, Hif-2a, and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.
Abbreviation: SIRT1
UniProt: Q96EB6, Q923E4, Q96EB6
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse SIRT1
Target: 75SirT1; hSIR2; hSIRT1; HST2; S. cerevisiae; homolog of; NAD dependent deacetylase sirtuin 1; NAD dependent protein deacetylase sirtuin 1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; SIR1; SIR2; SIR2 like 1; SIR2 like protein 1; SIR2; S.cerevisiae; homolog-like 1; SIR2-like protein 1; SIR2ALPHA; SIR2L1; Sirt1; SirtT1 75 kDa fragment; Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) ; Sirtuin 1; Sirtuin type 1
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Tags and Cell Markers
Purification: Affinity purification
Concentration: 0.57 mg/mL
Dilution: IHC 1:200-1:800
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Citation 01: https://link.springer.com/article/10.1007/s10571-019-00710-7
Isotype: IgG

Frequently Asked Questions

What is the catalog number for SIRT1 Polyclonal Antibody?

The catalog number for SIRT1 Polyclonal Antibody is E-AB-70071.

What sizes are available for SIRT1 Polyclonal Antibody?

SIRT1 Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does SIRT1 Polyclonal Antibody come in?

SIRT1 Polyclonal Antibody is available in 3 different pack sizes.

Is SIRT1 Polyclonal Antibody in stock?

SIRT1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SIRT1 Polyclonal Antibody?

SIRT1 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for SIRT1 Polyclonal Antibody?

Estimated delivery time for SIRT1 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SIRT1 Polyclonal Antibody?

The safety data sheet for SIRT1 Polyclonal Antibody is available here: https://789.bio/eb/TCCqPO.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.