FOXO1 Polyclonal Antibody

Specifications

Catalog number

E-AB-70144-01

Size / count

60 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

FOXO1, also named as FOXO1A, FKHR and FKH1, is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1, FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24, Ser-256, and Ser-319) that are conserved in other FOXO proteins. The t (2;13) and the variant t (1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2) .

Abbreviation

FOXO1

UniProt

Q12778, Q9R1E0, G3V7R4

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein corresponding to Mouse FOXO1

Target

FKH 1; FKH1; FKHR; Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) ; Forkhead box O1; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Forkhead; Drosophila; homolog of; in rhabdomyosarcoma; FoxO transcription factor; foxo1; FOXO1; FOXO1A; OTTHUMP00000018301

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Epigenetics and Nuclear Signaling; Metabolism; Neuroscience; Signal Transduction

Purification

Affinity purification

Concentration

320 μg/mL

Dilution

IHC 1:300-1:1000

Buffer

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG