Glucocorticoid Receptor Polyclonal Antibody

Specifications

Catalog number

E-AB-70157-01

Size / count

60 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.

Abbreviation

Glucocorticoid Receptor

UniProt

P04150, P06536, P06537

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant proteincorresponding to Mouse Glucocorticoid receptor

Target

GCCR; GCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; GRL; Grl1; nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3; group C; member 1 (glucocorticoid receptor)

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Epigenetics and Nuclear Signaling; Signal Transduction

Purification

Affinity purification

Concentration

1.3 mg/mL

Dilution

WB 1:500-1:1000; IHC 1:500-1:1000

Buffer

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

91kDa

Observed Molecular Weight

91kDa

Isotype

IgG