Product details

MGMT Polyclonal Antibody

Catalog number E-AB-70262-01

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Price for E-AB-70262-01

Size / count 60 µL

Specifications

Catalog number: E-AB-70262-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.
Abbreviation: MGMT
UniProt: P26187, P24528
Host: Rabbit
Reactivity: Mouse; Rat
Immunogen: Recombinant protein corresponding to Mouse MGMT
Target: 6 O methylguanine DNA methyltransferase;6-O-methylguanine-DNA methyltransferase; Agat; AGT; AI267024; EC 2.1.1.63; Methylated DNA protein cysteine methyltransferase; Methylated-DNA--protein-cysteine methyltransferase; Methylguanine DNA methyltransferase; MGC107020; MGMT; MGMT; O 6 methylguanine DNA alkyltransferase; O 6 methylguanine DNA methyltransferase; O-6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Epigenetics and Nuclear Signaling
Purification: Affinity purification
Concentration: 260 μg/mL
Dilution: IHC 1:100-1:500
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for MGMT Polyclonal Antibody?

The catalog number for MGMT Polyclonal Antibody is E-AB-70262.

What sizes are available for MGMT Polyclonal Antibody?

MGMT Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does MGMT Polyclonal Antibody come in?

MGMT Polyclonal Antibody is available in 3 different pack sizes.

Is MGMT Polyclonal Antibody in stock?

MGMT Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MGMT Polyclonal Antibody?

MGMT Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for MGMT Polyclonal Antibody?

Estimated delivery time for MGMT Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MGMT Polyclonal Antibody?

The safety data sheet for MGMT Polyclonal Antibody is available here: https://789.bio/eb/XTqr1G.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.