CASP3 Polyclonal Antibody — image 1 of 2

Product details

CASP3 Polyclonal Antibody

Catalog number E-AB-70388-01

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Price for E-AB-70388-01

Size / count 60 µL

Specifications

Catalog number: E-AB-70388-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 (also named CPP32, SCA-1, and Apopain) proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at the beginning of apoptosis. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Abbreviation: CASP3
UniProt: P70677, P42574, P55213
Host: Rabbit
Reactivity: Human; Mouse
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse caspase3
Target: A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Cell Biology; Metabolism; Neuroscience
Purification: Affinity purification
Concentration: 500 μg/mL
Dilution: IHC 1:200-1:800
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for CASP3 Polyclonal Antibody?

The catalog number for CASP3 Polyclonal Antibody is E-AB-70388.

What sizes are available for CASP3 Polyclonal Antibody?

CASP3 Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does CASP3 Polyclonal Antibody come in?

CASP3 Polyclonal Antibody is available in 3 different pack sizes.

Is CASP3 Polyclonal Antibody in stock?

CASP3 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CASP3 Polyclonal Antibody?

CASP3 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for CASP3 Polyclonal Antibody?

Estimated delivery time for CASP3 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CASP3 Polyclonal Antibody?

The safety data sheet for CASP3 Polyclonal Antibody is available here: https://789.bio/eb/evXPi9.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.