Recombinant Lactate Dehydrogenase A Monoclonal Antibody

Specifications

Catalog number

E-AB-81451-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

LDHA, also named as LDH-M and NY-REN-59, is an enzyme which catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria. LDHA has some isoforms with MW 26-40 kDa.

Abbreviation

Lactate Dehydrogenase A

UniProt

P00338

Host

Rabbit

Reactivity

Human; Rat

Immunogen

A synthetic peptide of human Lactate Dehydrogenase

Target

Cell proliferation-inducing gene 19 protein; GSD11; L lactate dehydrogenase A chain; l7R2; LDH M; LDH muscle subunit; LDH1; PIG19 Proliferation-inducing gene 19

Clonality

Monoclonal

Clone

R09-9A7

Conjugation

Unconjugated

Applications

WB

Field of Research

Cancer; Metabolism; Signal Transduction

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:1000-1:2000

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

37kDa

Observed Molecular Weight

37kDa

Isotype

IgG