Recombinant ALIX Monoclonal Antibody

Specifications

Catalog number

E-AB-81456-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Abbreviation

ALIX

UniProt

Q8WUM4

Host

Rabbit

Reactivity

Human; Rat; Hamster

Immunogen

Recombinant protein of human ALIX

Target

PDCD6IP; AIP1; ALIX; DRIP4; HP95

Clonality

Monoclonal

Clone

R03-8C2

Conjugation

Unconjugated

Applications

WB

Field of Research

Cell Biology; Microbiology; Signal Transduction

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:1000-1:2000

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

96kDa

Observed Molecular Weight

96kDa

Isotype

IgG