Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody

Specifications

Catalog number

E-AB-81487-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5' -CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.

Abbreviation

Transcription Factor 7 Like 2

UniProt

Q9NQB0

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide of human TCF-4

Target

TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4

Clonality

Monoclonal

Clone

R09-1D1

Conjugation

Unconjugated

Applications

WB; IHC-P

Field of Research

Epigenetics and Nuclear Signaling; Cardiovascular; Metabolism

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:500-1:1000; IHC 1:50-1:100

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

68kDa

Observed Molecular Weight

68kDa

Isotype

IgG