Recombinant Collagen I alpha 1 Monoclonal Antibody

Specifications

Catalog number

E-AB-81499-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I. Among its related pathways are Collagen chain trimerization and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include identical protein binding and platelet-derived growth factor binding. An important paralog of this gene is COL2A1.This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Abbreviation

Collagen I alpha 1

UniProt

P02452

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein of human Collagen I

Target

COL1A1; Alpha 1 type I collagen; Alpha-1 type I collagen; CO1A1; COL1A1; Collagen alpha-1 (I) chain; Collagen type I alpha 1; Procollagen type I C terminal propeptide

Clonality

Monoclonal

Clone

R02-5E5

Conjugation

Unconjugated

Applications

WB

Field of Research

Signal Transduction

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:500-1:1000

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

139kDa

Observed Molecular Weight

139kDa

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1111/tmi.13359

Isotype

IgG