Recombinant ApoER2 Monoclonal Antibody

Specifications

Catalog number

E-AB-81530-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE) -containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP) . Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 . Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells .

Abbreviation

ApoER2

UniProt

Q14114

Host

Rabbit

Reactivity

Human; Rat; Hamster

Immunogen

A synthetic peptide of human ApoER2

Target

MCI1; LRP-8; APOER2; HSZ75190

Clonality

Monoclonal

Clone

R03-1H8

Conjugation

Unconjugated

Applications

WB

Field of Research

Neuroscience; Signal Transduction; Cardiovascular; Metabolism

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:500-1:2000

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

106kDa

Observed Molecular Weight

106kDa

Isotype

IgG