Recombinant Chk2 Monoclonal Antibody

Catalog number E-AB-81546-01

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Price for E-AB-81546-01

Size / count 50 µL

Specifications

Catalog number: E-AB-81546-01
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
Abbreviation: Chk2
UniProt: O96017
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant protein of human Chk2
Target: CDS 1; Cds1; Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; CHEK 2; Chek2; Chk 2; CHK2 checkpoint homolog (S. pombe) ; CHK2 checkpoint homolog; CHK2; hCds1; HuCds 1; LFS 2; LFS2; PP1425; RAD 53; RAD53; Rad53 homolog; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2
Clonality: Monoclonal
Clone: R04-8E5
Conjugation: Unconjugated
Applications: WB
Field of Research: Cancer; Epigenetics and Nuclear Signaling
Purification: Affinity Purified
Concentration: 300 μg/mL
Dilution: WB 1:500-1:1000
Buffer: 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 61kDa
Observed Molecular Weight: 61kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for Recombinant Chk2 Monoclonal Antibody?

The catalog number for Recombinant Chk2 Monoclonal Antibody is E-AB-81546.

What sizes are available for Recombinant Chk2 Monoclonal Antibody?

Recombinant Chk2 Monoclonal Antibody is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Recombinant Chk2 Monoclonal Antibody come in?

Recombinant Chk2 Monoclonal Antibody is available in 2 different pack sizes.

Is Recombinant Chk2 Monoclonal Antibody in stock?

Recombinant Chk2 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Chk2 Monoclonal Antibody?

Recombinant Chk2 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Chk2 Monoclonal Antibody?

Estimated delivery time for Recombinant Chk2 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Chk2 Monoclonal Antibody?

The safety data sheet for Recombinant Chk2 Monoclonal Antibody is available here: https://789.bio/eb/8a5SqP.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.