Recombinant Glucocorticoid Receptor Monoclonal Antibody

Specifications

Catalog number

E-AB-81561-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor for glucocorticoids (GC) . Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832) . Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546) .

Abbreviation

Glucocorticoid Receptor

UniProt

P06537

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of mouse Glucocorticoid Receptor

Target

GR; GCR; GRL; GCCR; GCRST

Clonality

Monoclonal

Clone

R04-8C8

Conjugation

Unconjugated

Applications

WB; IF

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:500-1:1000; IF 1:50-1:100

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

86kDa

Observed Molecular Weight

94/91kDa

Isotype

IgG