Recombinant Integrin beta 5 Monoclonal Antibody

Specifications

Catalog number

E-AB-81574-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors.

Abbreviation

Integrin beta 5

UniProt

P18084

Host

Rabbit

Reactivity

Human; Rat; Hamster

Immunogen

Recombinant protein of human Integrin beta 5

Target

FLJ26658; Integrin beta-5; Integrin subunit beta 5; integrin; beta 5; ITB5; Itgb5; Testis secretory sperm-binding protein Li 217p

Clonality

Monoclonal

Clone

R04-0G6

Conjugation

Unconjugated

Applications

WB

Field of Research

Cancer; Signal Transduction

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:500-1:1000

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

88kDa

Observed Molecular Weight

88kDa

Isotype

IgG