Recombinant Presenilin 1 Monoclonal Antibody

Specifications

Catalog number

E-AB-81599-01

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Abbreviation

Presenilin 1

UniProt

P49768

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide of human Presenilin 1

Target

AD3; FAD; PS-1; PS1; S182; Presenilin 1; PSEN1

Clonality

Monoclonal

Clone

R05-4D4

Conjugation

Unconjugated

Applications

WB

Field of Research

Cancer; Metabolism; Neuroscience; Signal Transduction

Purification

Affinity Purified

Concentration

300 μg/mL

Dilution

WB 1:1000-1:2000

Buffer

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

53kDa

Observed Molecular Weight

20kDa

Isotype

IgG