STAT3 Polyclonal Antibody

Specifications

Catalog number

E-AB-93190-01

Size / count

60 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Abbreviation

STAT3

UniProt

P40763

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant fusion protein of human STAT3

Target

ADMIO; ADMIO1; APRF; HIES; STAT3; Stat3

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB

Field of Research

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Developmental Biology; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000

Buffer

PBS with 0.01% thiomersal,50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

83kDa/87kDa/88kDa

Observed Molecular Weight

79KDa

Isotype

IgG