Recombinant Human NCR2/NKp44/CD336 Protein (His Tag)

Specifications

Catalog number

PDMH100003-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Natural cytotoxicity triggering receptor 2 (NCR2), also known as Natural killer cell p44-related protein (NKp44), or CD336, is a member of the natural cytotoxicity receptor (NCR) family, which composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. It is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The cytoplasmic domain of NKp44 also contains a sequence that matches the immunoreceptor tyrosine-based inhibitory motif (ITIM) consensus. This Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp44 is selectively expressed by IL-2-activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Tumor cell recognition of the mutated NKp44 proteins was significantly reduced and correlated with their lower recognition of heparin.

Abbreviation

NCR2; NKp44; CD336

Synonyms

CD336; LY95; NK-p44; NKP44; RP1-149M18.2; dJ149M18.1

UniProt

O95944

Accession Number

O95944

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Pro 190

Field of Research

Signal Transduction; immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 88% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.0 kDa

Observed Molecular Weight

37 kDa

Species

Human