Recombinant Human CC16 protein (His tag)

Specifications

Catalog number

PDMH100049-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Uteroglobin is a small, non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated, non-mucous secretory cells that predominate in lung bronchioles (Clara cells), and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen, and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids, progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy, while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion.

Abbreviation

Uteroglobin; SCGB1A1

Synonyms

CC10; CCPBP; CCSP; Clara cell phospholipid-binding protein; Clara cells 10 kDa secretory protein; SCGB1A1; Secretoglobin family 1A member 1; UGB; UP-1; UP1; Urinary protein 1; Urine protein 1; Uteroglobin

UniProt

P11684

Accession Number

P11684

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu22-Asn91

Field of Research

Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

9.9 kDa

Observed Molecular Weight

10 kDa

Species

Human