Recombinant Human CD5L/hAIM protein (His tag)

Specifications

Catalog number

PDMH100080-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD5 Antigen-Like (CD5L) is a soluble protein that belongs to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. CD5L is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues. It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram-negative bacteria and the SRCR domain one of CD5L retains both the LPS and LTA binding activities. Furthermore, CD5L seems to play a role as an inhibitor of apoptosis.

Abbreviation

CD5L; hAIM

Synonyms

API6; Apoptosis inhibitor expressed by macrophages; CD5 antigen-like; CD5L; CT-2; IgM-associated peptide; SP-alpha; UNQ203/PRO229; hAIM

UniProt

O43866

Accession Number

O43866

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Gly347

Field of Research

Cell Biology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.1 kDa

Observed Molecular Weight

42 kDa

Species

Human