Recombinant Human AGER protein (His tag)

Specifications

Catalog number

PDMH100123-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Advanced Glycosylation End Product-Specific Receptor (AGER) belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

Abbreviation

AGER

Synonyms

AGER; Advanced Glycosylation End Product-Specific Receptor; RAGE; Receptor for Advanced Glycosylation End Products

UniProt

Q15109

Accession Number

Q15109

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Ala342

Field of Research

Cardiovascular; Neuroscience

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.5 kDa

Observed Molecular Weight

45 kDa

Species

Human