Recombinant Human CD48 protein (His tag)

Specifications

Catalog number

PDMH100144-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1, and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, but does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cell activation. CD48 plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma.

Abbreviation

CD48

Synonyms

B-lymphocyte activation marker BLAST-1; BCM1; BCM1 surface antigen; BLAST1; CD48; CD48 antigen; Leukocyte antigen MEM-102; SLAMF2; TCT.1; hCD48; mCD48

UniProt

P09326

Accession Number

P09326

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Ser220

Field of Research

Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.1 kDa

Observed Molecular Weight

38 kDa

Species

Human