Recombinant Human TNFSF4/OX40L protein (His tag)

Specifications

Catalog number

PDMH100152-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor ligand superfamily member 4 (TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional, it has been found association with systemic lupus erythematosus, no association with occurrence of atherosclerosis.

Abbreviation

TNFSF4; OX40L

Synonyms

CD134L; CD252; GP34; Glycoprotein Gp34; OX-40; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; TXGP1; Tumor necrosis factor ligand superfamily member 4

UniProt

P23510

Accession Number

P23510

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln51-Leu183

Field of Research

Immunology; Stem cells

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.5 kDa

Observed Molecular Weight

30 kDa

Species

Human