Recombinant Rat IL-4 Protein

Specifications

Catalog number

PDMR100003-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.

Abbreviation

IL-4

Synonyms

Interleukin; B-cell growth factor; B-cell stimulatory factor; Lymphocyte stimulatory factor; BCGF1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BCGF-1; Binetrakin; BSF1; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra; Il4; BSF-1; Lymphocy; Il 4; B-cell growth factor 1; Il-4; IL4、BCGF-1、BCGF1、BSF-1、BSF1

UniProt

P20096

Accession Number

P20096

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Ser147

Field of Research

Cancer; Cardiovascular; Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.5 kDa

Observed Molecular Weight

17 kDa

Species

Rat