Recombinant Human CD20/MS4A1 Protein (TrxA Tag)

Specifications

Catalog number

PKSH030304

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD20 (membrane-spanning 4-domains; subfamily A; member 1) ; also known as MS4A1; is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells; but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) . CVID5 is a primary immunodeficiency characterized by antibody deficiency; hypogammaglobulinemia; recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range; but can be low.

Synonyms

B1; Bp35; CD20; CVID5; LEU-16; MS4A1; MS4A2; S7

UniProt

P11836

Accession Number

NP_068769.2

Expression System

E.coli

Tag

N-Trx

Sequence

Ile 141-Ser 188

Field of Research

Cancer; immunology; Stem cells

Endotoxin

Please contact us for more information.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

23.9 kDa

Species

Human