Recombinant Human IHPK1 Protein (His & GST Tag)

Specifications

Catalog number

PKSH030322

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IHPK1 is a inositol hexaphosphate kinase (IHPK) protein which belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) . IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. During cell death, IHPK1 activity is enhanced, and intracellular InsP7 level is augmented. The distribution of IHPK1 or another predisposing gene affected by position effect of translocation may explain the T2DM phenotype at least in this family.

Synonyms

IHPK1; PiUS

UniProt

Q92551

Accession Number

Q92551-1

Expression System

Baculovirus-Insect Cells

Tag

N-His-GST

Sequence

Met 1-Gln 441

Field of Research

Signal Transduction, Metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

78.0 kDa

Observed Molecular Weight

88 kDa

Formulation

Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol

Species

Human