Recombinant Human MVK/Mevalonate kinase Protein (His & GST Tag)

Specifications

Catalog number

PKSH030326

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA) . It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in mevalonate kinase can also cause hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) . HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis.

Synonyms

LRBP; MK; MVLK; POROK3

UniProt

Q03426

Accession Number

Q03426

Expression System

Baculovirus-Insect Cells

Tag

N-His-GST

Sequence

Met 1-Leu 396

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

70.2 kDa

Observed Molecular Weight

47 kDa

Formulation

Supplied as sterile solution of 20mM Tris, 500mM NaCl, 2mM DTT, pH 7.4, 10% glycerol

Species

Human