Recombinant Human SPEG/APEG-1 Protein (His Tag)

Specifications

Catalog number

PKSH030334

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains twofibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform1of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform3of SPEG is predominantly expressed in the aorta. Isoform3of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform3of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform3of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.

Synonyms

APEG-1; APEG1; BPEG; CNM5; SPEGalpha; SPEGbeta

UniProt

Q15772

Accession Number

Q15772-4

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Glu 113

Field of Research

Cardiovascular

Endotoxin

Please contact us for more information.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

14 kDa

Observed Molecular Weight

19 kDa

Formulation

Supplied as sterile solution of PBS, pH 7.4

Species

Human