Recombinant Human GALK1/Galactokinase Protein (His & GST Tag)

Specifications

Catalog number

PKSH030368

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Galactokinase; also known as Galactose kinase; GALK and GALK1; is a protein which belongs to theGHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by elevation of blood galactose concentration and diminished galactose-1-phosphate; leading to the production of galactitol. Defects in GALK1 are the cause of galactosemia II (GALCT2) which II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.

Synonyms

GALK; GALK1; Galactokinase; Galactose Kinase

UniProt

P51570

Accession Number

P51570

Expression System

Baculovirus-Insect Cells

Tag

N-His-GST

Sequence

Met 1-Leu 392

Field of Research

Signal Transduction; Cell biology; Cancer; epigenetics and nuclear signal; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

70.0 kDa

Observed Molecular Weight

60 kDa

Formulation

Supplied as sterile solution of 20mM Tris, 500mM NaCl, 2mM GSH, pH 8.0

Species

Human