Recombinant Human BMPR1B/ALK-6 Protein (aa 149-502, His&GST Tag)

Specifications

Catalog number

PKSH030412

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

BMPR1B (bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

Synonyms

ALK-6; ALK6; CDw293

UniProt

O00238

Accession Number

NP_001194.1

Expression System

Baculovirus-Insect Cells

Tag

N-His-GST

Sequence

Arg 149-Leu 502

Field of Research

Signal Transduction; epigenetics and nuclear signal; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

68.3 kDa

Observed Molecular Weight

55 kDa

Formulation

Supplied as sterile solution of 50mM Tris, 100mM NaCl, pH 8.5, 20% glycerol, 0.3mM DTT

Species

Human