Recombinant Human TL1A Protein (Fc Tag)

Specifications

Catalog number

PKSH030438

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro) . TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

Synonyms

TL1; TL1A; TNF Ligand-Related Molecule 1; TNFSF15; Tumor Necrosis Factor Ligand Superfamily Member 15; VEGI; Vascular Endothelial Cell Growth Inhibitor

UniProt

O95150

Accession Number

NP_005109.2

Expression System

HEK293 Cells

Tag

N-hFc

Sequence

Leu72-Leu251

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.9 kDa

Species

Human