Recombinant Human BBOX1/Gamma-BBH Protein (His & GST Tag)

Specifications

Catalog number

PKSH030526

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treatanginaandmyocardial infarction. Mildronate may also be beneficial for the treatment ofneurological disorder, diabetes, andseizures andalcohol intoxication.

Synonyms

BBH; BBOX; G-BBH; gamma-BBH

UniProt

O75936

Accession Number

O75936

Expression System

Baculovirus-Insect Cells

Tag

N-His-GST

Sequence

Met 1-Asn387

Field of Research

Signal Transduction; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

72.5 kDa

Observed Molecular Weight

65 kDa

Species

Human