Recombinant Human APLP-1 Protein (aa 1-580, His Tag)

Specifications

Catalog number

PKSH030570

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP) . APP is a type I membrane protein that is genetically linked to Alzheimer's disease.

Synonyms

APLP; APLP-1; APLP1; Amyloid-like protein 1; C30

UniProt

P51693

Accession Number

P51693-1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Glu580

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

61.9 kDa

Observed Molecular Weight

67-77 kDa

Species

Human