Recombinant Human ILT6/LILRA3 Protein (Fc Tag)

Specifications

Catalog number

PKSH030602

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

Synonyms

CD85 antigen-like family member E; CD85e; HM31; HM43; ILT-6; ILT6; Immunoglobulin-like transcript 6; LIR-4; LIR-4 and Monocyte inhibitory receptor HM43/HM31; LIR4; Leukocyte immunoglobulin-like receptor 4; Leukocyte immunoglobulin-like receptor subfamily A member 3

UniProt

Q8N6C8

Accession Number

AAH28208.1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Glu439

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

72.0 kDa

Observed Molecular Weight

102 kDa

Species

Human