Recombinant Human Reticulocalbin 3/RCN3 Protein (aa 1-324, His Tag)

Specifications

Catalog number

PKSH030608

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

RCN3 belongs to the CREC family which contains multiple EF-hand Ca2+-binding proteins localized to the secretory pathway. RCN3 sequence is characterized by the presence of five Arg-Xaa-Xaa-Arg motifs; which represents the target sequence of subtilisin-like proprotein convertases (SPCs) . SPCs are a family of seven structurally related serine endoproteases that are involved in the proteolytic activation of proproteins.RCN3 is transiently associated with proPACE4; but not with mature PACE4. Inhibition of PACE4 maturation by a Ca2+ ionophore resulted in accumulation of the proPACE4-RCN-3 complex in cells. It has been proposed that elective and transient association of RCN3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.

Synonyms

EF-Hand Calcium-Binding Protein RLP49; RCN3; Reticulocalbin-3

UniProt

Q96D15

Accession Number

Q96D15

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-His324

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.2 kDa

Species

Human