Recombinant Human IgG2-Fc Protein (257 Ser/Ala)

Specifications

Catalog number

PKSH030615-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SCN3B (sodium channel; voltage-gated; type III; beta ; human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B gene encodes one member of the sodium channel beta subunit gene family; and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants; encoding the same protein; have been identified. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation) ; the individual will faint and may die in a few minutes if the heart is not reset.

Synonyms

Ig gamma-2 chain C region; IgG2 Fc

UniProt

P01859

Accession Number

P01859

Expression System

HEK293 Cells

Tag

None

Sequence

Glu 99-Lys 327; 257Ser/Ala

Applications

ELISA

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to bind human CD32a-His in a functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25 kDa

Observed Molecular Weight

34 kDa

Species

Human