Recombinant Human DCX Protein (aa 45-150, GST Tag)

Specifications

Catalog number

PKSH030620

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

DCX (doublecortin, N-GST chimera) contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it is highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. DCX is a microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. It may act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. DCX may in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. It may be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Defects in DCX are the cause of lissencephaly X-linked type 1 and subcortical band heterotopia X-linked.

Synonyms

DBCN; DC; LISX; SCLH; XLIS

UniProt

O43602

Accession Number

O43602-2

Expression System

E.coli

Tag

N-GST

Sequence

Ala 45-Val 150

Field of Research

Neuroscience, Tags & Cell Markers

Endotoxin

Please contact us for more information.

Purity

> 82 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

39.4 kDa

Observed Molecular Weight

36 kDa

Species

Human