Recombinant Human Jumping Translocation Breakpoint/JTB Protein (Fc Tag)

Specifications

Catalog number

PKSH030629

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.

Synonyms

HJTB; HSPC222; JTB; PAR; hJT

UniProt

O76095

Accession Number

O76095-1

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Met 1-Leu105

Field of Research

Cell Biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

34.7 kDa

Observed Molecular Weight

38 kDa

Species

Human