Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

Specifications

Catalog number

PKSH030653-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.

Abbreviation

PGD2 Synthase; PTGDS

Synonyms

Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; PDS; PGD2 Synthase; PGDS; PGDS2; PTGDS; Prostaglandin D Synthase; Prostaglandin-D2 Synthase; Prostaglandin-H2 D-Isomerase

UniProt

P41222

Accession Number

P41222

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala23-Gln190

Field of Research

Signal Transduction

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

19.7 kDa

Observed Molecular Weight

20-27 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.

Citation 01

https://www.mdpi.com/2218-1989/12/4/355

Species

Human