Recombinant Human PPIase/FKBP7 Protein (aa 1-218, His Tag)

Specifications

Catalog number

PKSH030674

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family; PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels; and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse; deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Synonyms

23 kDa FK506-Binding Protein;23 kDa FKBP; FK506-Binding Protein 7; FKBP-23; FKBP-7; FKBP23; FKBP7; PPIase FKBP7; Peptidyl-Prolyl Cis-Trans Isomerase FKBP7; Rotamase

UniProt

Q9Y3C6

Accession Number

Q9Y3C6

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Gln218

Field of Research

Signal Transduction; epigenetics and nuclear signal; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

23.8 kDa

Observed Molecular Weight

27-30 kDa

Species

Human