Recombinant Human LRP10 Protein (Fc Tag)

Specifications

Catalog number

PKSH030687

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN) ; plasma membrane (PM) ; and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing; suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.

Synonyms

LRP9; MST087; MSTP087

UniProt

Q7Z4F1

Accession Number

Q7Z4F1-1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Lys 440

Field of Research

Stem Cells, Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 88 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

73.0 kDa

Observed Molecular Weight

80-90 kDa

Species

Human