Recombinant Human TRP1/TYRP1 Protein (Human Cells, His Tag)

Specifications

Catalog number

PKSH030692

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tyrosinase-related protein 1; also known as TYRP1 or TRP1; is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5;6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5;6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF) . There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis; TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

Synonyms

CAS2; CATB; GP75; OCA3; TRP; TRP1; TYRP; b-PROTEIN

UniProt

P17643

Accession Number

P17643

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1- Arg 471

Field of Research

Signal Transduction; Tags & Cell Markers; Cell biology; Cancer; epigenetics and nuclear signal; immunology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

52.2 kDa

Observed Molecular Weight

66 kDa

Species

Human