Recombinant Human IFNAR1/IFNAR Protein (Fc Tag)

Specifications

Catalog number

PKSH030696

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases; which in turn phosphorylate several proteins; including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due; at least in part; to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1; in which Tyr466 is changed to phenylalanine; can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Synonyms

AVP; CRF2-1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; IFN-Alpha/Beta Receptor 1; IFN-R-1; IFN-alpha-REC; IFNAR; IFNAR1; Interferon Alpha/Beta Receptor 1; Type I Interferon Receptor 1

UniProt

P17181

Accession Number

P17181-1

Expression System

HEK293 Cells

Tag

C-hFc

Sequence

Met 1-Lys 436

Field of Research

Immunology, Signal Transduction, Epigenetics and Nuclear Signaling

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 88 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

74.0 kDa

Observed Molecular Weight

100-120 kDa

Species

Human