Recombinant Human STAT6 Protein (Baculovirus, His Tag)

Specifications

Catalog number

PKSH030708

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4) -induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP) . NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.

Synonyms

IL-4 Stat; IL-4-STAT; STAT6; STAT6B; STAT6C; Signal Transducer and Activator of Transcription 6

UniProt

P42226

Accession Number

P42226-1

Expression System

Baculovirus-Insect Cells

Tag

C-His

Sequence

Met 1-Trp 847

Field of Research

Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Kits, Lysates, Other

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

95.5 kDa

Observed Molecular Weight

100 kDa

Species

Human