Recombinant Human TNFSF4/OX40L Protein (Fc Tag)

Specifications

Catalog number

PKSH030721-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Synonyms

CD134L; CD252; GP34; Glycoprotein Gp34; OX-40; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; TXGP1; Tumor necrosis factor ligand superfamily member 4

UniProt

P23510

Accession Number

NP_003317.1

Expression System

HEK293 Cells

Tag

N-mFc

Sequence

Gln51-Leu183

Field of Research

Immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.1 kDa

Species

Human