Recombinant Human PRL-2/PTP4A2 Protein (GST Tag)

Specifications

Catalog number

PKSH030728

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeutic targets. PRL-1, PRL-2, and PRL-3 represent a novel class of protein-tyrosine phosphatase with a C-terminal prenylation motif. They are three closely related intracellular enzymes that possess the PTP active site signature sequence CX 5R. The PRL-2 mRNA is elevated in primary breast tumors relative to matched normal tissue, and also dramatically elevated in metastatic lymph nodes compared with primary tumors. PRL-2 plays a role in breast cancer progression. PRL-2 is a pathogenic molecule in hematopoietic malignancies and suggest its potential as a novel therapeutic target.

Synonyms

HH13; HH7-2; HMT; HNMT-S1; HNMT-S2; HU-PP-1; OV-1; PRL-2; PRL2; PTP (CAAXII) ; PTP4A; PTP4A2; PTPCAAX2; Protein tyrosine phosphatase type IVA 2; Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; ptp-IV1a; ptp-IV1b

UniProt

Q12974

Accession Number

Q12974-1

Expression System

E.coli

Tag

N-GST

Sequence

Asn 2-Gln 167

Field of Research

Cell Biology, Signal Transduction, Cancer

Endotoxin

Please contact us for more information.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

45.9 kDa

Observed Molecular Weight

45 kDa

Species

Human