Recombinant Human TXNRD1/TRXR1 Protein (aa 161-647, His Tag)

Specifications

Catalog number

PKSH030732

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.

Synonyms

GRIM-12; TR; TR1; TRXR1; TXNR

UniProt

Q16881

Accession Number

Q16881-1

Expression System

E.coli

Tag

N-His

Sequence

Tyr 161-Cys 647

Field of Research

Signal Transduction, Cell Biology, Metabolism

Endotoxin

Please contact us for more information.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

55.0 kDa

Observed Molecular Weight

60 kDa

Species

Human