Recombinant Human IL17BR/IL17RB Protein (His Tag)

Specifications

Catalog number

PKSH030735

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.

Abbreviation

IL17BR/IL17RB

Synonyms

CRL; EVI; UNQ; IL17RH; IL17RB; CRL4; EVI27; IL17BR; IL17RH1; UNQ2501; PRO19612; CRL 4; Cytokine receptor CRL4; EVI 27; IL 17 receptor B; IL 17 receptor homolog 1; IL 17B receptor; IL 17RB; IL 17Rh1; Interleukin 17 receptor B; Interleukin 17 receptor homolog; Interleukin 17 receptor homolog 1; Interleukin 17B receptor; MGC5245

UniProt

Q9NRM6

Accession Number

NP_061195.2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Gly289

Applications

ELISA

Field of Research

Cell biology; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized human IL17BR-His at 10 μg/ml (100 μl/well) can bind human Fc-IL25, The EC50 of human Fc-IL25 is 0.1-0.3 μg/ml.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

31.5 kDa

Observed Molecular Weight

41-45 kDa

Species

Human