Recombinant Human KIR2DL4/CD158D Protein

Specifications

Catalog number

PKSH030752

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.

Synonyms

CD158 Antigen-Like Family Member D; CD158D; CD158d; G9P; KIR-103AS; KIR103AS; KIR2DL4; Killer Cell Immunoglobulin-Like Receptor 2DL4; Killer Cell Inhibitory Receptor 103AS; MHC Class I NK Cell Receptor KIR103AS

Accession Number

ADY38409.1

Expression System

CHO Stable Cells

Tag

None

Sequence

Met 1-His242

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.1 kDa

Observed Molecular Weight

33-37 kDa

Species

Human