Recombinant Human IL1RL1/ST2 Protein (isoform a, His Tag)

Specifications

Catalog number

PKSH030755

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL-1 receptor– like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

Abbreviation

IL1RL1/ST2

Synonyms

FIT; DER; IL1RL; IL-1 R; IL1RL1; DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1; IL-1 R4; DER-4; FIT 1; Growth stimulation expressed; Growth stimulation expressed gene 2; homolog of mouse growth stimulation-expressed; IL-1R4; ILRL1; Interleukin 1 receptor like 1; interleukin 1 receptor related protein; Interleukin-1 receptor-like 1; Protein ST2; T1 protein

UniProt

Q01638

Accession Number

NP_057316.3

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Ser 328

Applications

ELISA

Field of Research

Cardiovascular; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized recombinant human IL33 at 10 μg/mL (100 μl/well) can bind biotinylated human IL1RL1 (isoform A) with a linear range of 0.032-8 μg/ml.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.3 kDa

Species

Human