Recombinant Human PTPMT1 Protein (His Tag)

Specifications

Catalog number

PKSH030769

Size / count

50 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an accumulation of PGP along with a concomitant decrease in phosphatidylglycerol. Modulation of mitochondrial ATP synthesis by PTPMT1 suggests a novel approach for the treatment of pancreatic cancers, which represent some of the deadliest forms of human tumors. The gluttony of cancer cells for energy is well established, and with the development of a modulator of expression, one may hope that we could also achieve the synthetic induction of PTPMT1 expression. It would then be expected that this effect would attenuate, if not abolish, the growth of pancreas-derived tumor cells and support the establishment of a novel regimen for pancreatic cancers.

Synonyms

DUSP23; FLJ46081; MOSP; PLIP; PNAS-129

UniProt

Q8WUK0

Accession Number

Q8WUK0-1

Expression System

E.coli

Tag

N-His

Sequence

Lys 28-Thr 201

Applications

Enzyme

Field of Research

Tags & Cell Markers, Signal Transduction

Endotoxin

Please contact us for more information.

Purity

> 94 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to cleave pNPP. The specific activity is > 200 pmoles/min/μg.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

21.7 kDa

Observed Molecular Weight

20 kDa

Species

Human