Recombinant Human CRADD/RAIDD Protein (His Tag)

Specifications

Catalog number

PKSH030770

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Death domain-containing protein CRADD; also known as Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CRADD and RAIDD; is a protein which is constitutively expressed in most tissues; with particularly high expression in adult heart; testis; liver; skeletal muscle; fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. FADD / MORT1 is a death domain (DD) -containing adaptor / signaling molecule that interacts with the intracellular DD of FAS / APO-I (CD95) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 (Mch5 / MACH / FLICE) . CRADD / RAIDD has a dual-domain structure similar to that of FADD. CRADD / RAIDD has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD / RAIDD could play a role in regulating apoptosis in mammalian cells. CRADD / RAIDD is a apoptotic adaptor molecule specific for caspase-2 and FASL / TNF receptor-interacting protein RIP. In the presence of RIP and TRADD; CRADD / RAIDD recruits caspase-2 to the TNFR-1 signalling complex.

Synonyms

CRADD; Caspase and RIP Adapter with Death Domain; Death Domain-Containing Protein CRADD; RAIDD; RIP-Associated Protein with A Death Domain

UniProt

P78560

Accession Number

P78560

Expression System

E.coli

Tag

C-His

Sequence

Met 1-Glu 199

Field of Research

Cell biology; Cancer

Endotoxin

Please contact us for more information.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.1 kDa

Observed Molecular Weight

26 kDa

Species

Human